Ampoule

Your Professional Ampoule Manufacturer

Chongqing Zhengchuan Pharmaceutical Packaging Co., Ltd. is an enterprise that is professionally engaged in research, development, and production of pharmaceutical tubular glass vials and caps. Our products include: Pharmaceutical Glass Vials, Ampoule, Glass Tube, Vial Cap, Pre-filled Syringe, Rubber Stopper, Bottle Screen Printing, Irregular Shape Bottle, Cosmetic Bottle.

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Why Choose Us

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High Production Capacity The company has four branch factories and three large-sized production bases, covering a land of more than 200,000 m2. The company has 8 furnaces to produce glass tubing and more than 600 sets of high-precision devices used for production of vials and caps.

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Broad Market Relying on its great production capacity and famous brand, Zhengchuan has established a nationwide sales service network and has established long-term friendly cooperation relations with more than four hundred customers in China, which makes the company enjoy a good reputation at home and abroad.
Our products sell well in several regions in the world, e.g. South America, Southeast Asia, Europe and Asia.

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Wide Product Range The company possesses a modern technology research & development center and an integrated manufacturing center of pharmaceutical glass tubing, glass vials and auxiliary caps. The company mainly produces various types of transparent and amber tubular glass injection vials, tubular glass oral liquid vials, tubular glass screwed-neck vials and ampoules.

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Quality Assurance All products would enter a closed warehouse directly from the workshop via mechanical automation, so as to eliminate pollution sources due to transport of products and entrance of staffs and reduce the percentage of pollution and damage of products.

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What is Ampoule

An ampoule (also ampul and ampule) is a small sealed vial which is used to contain and preserve a sample, usually a solid or liquid. Ampoules are usually made of glass.
Modern ampoules are most commonly used to contain pharmaceuticals and chemicals that must be protected from air and contaminants. They are hermetically sealed by melting the thin top with an open flame, and usually opened by snapping off the neck. The space above the chemical may be filled with an inert gas before sealing. The walls of glass ampoules are usually sufficiently strong to be brought into a glovebox without any difficulty.

Benefits of Ampoule

Security Our glass ampoules are 100% tamper-proof.

Special Looks The transparency gives your product a very special appearance.

Light Protection Our amber glass ampoules protect light-sensitive contents.

High Quality Glass With our ampoules, you can also pack your high-quality contents accordingly.

Chemical Resistance Our glass ampoules have a very high hydrolytic resistance and are therefore very suitable for products that require a stable pH value.

Heat Sterilizability Our glass ampoules can be heat-sterilized so that they can be cleaned (Depyrogenation), the filling and the sterile sealing under optimal and before.

Durability Our ampoules have an almost unlimited shelf life. So are suitable they are ideal for storing parenteral fluids, for example.

Sustainability In addition, glass ampoules are easy to recycle, making them very sustainable.

Strength and Tightness You don't have to worry about fragility, nor about your contents evaporating or other ingredients escaping to the outside. Our ampoules are 100% tight and tight.

Interaction The contact between your product and our ampoule does not have "interactions".

Features of Ampoule

Ampoules for numerous drugs.
Amber and clear pharma glass type I.
Filling capacities from 1 to 30 ml.
Straight-stem, funnel-type and closed ampoules (ISO types B, C and D).
Customized shapes on request.
Break systems: One Point Cut, Colour Break Ring and Score Rin.
Targeted minimization and consistency of opening force.
Special treatment with ammonium sulfate for greater surface resistance.
Inner surface siliconization to provide a slide coating for optimum emptying of the ampoules.
Optimized designs for lyophilization.
Customized ceramic printing with heavy-metal-free inks.
Identification with up to three colored code rings.

Pharma Neutral Borosilicate Glass Tubes For Injection Bottles

Common Types of Ampoule

Pre-scored Ampoules

These pre-scored medical glass ampoules offer excellent biological product preservation and extended shelf life for injectable content. Ampoule stems can be flame sealed to provide tamper evidence and are pre-scored for easy opening.

Cryogenic Ampules

These pre-scored glass ampoules offer excellent preservation of biological content and are suitable for sterilization and gas-phase liquid nitrogen cold storage applications. Ampoule stems can be flame sealed to provide tamper evidence and are pre-scored for easy opening.

Lyophilization Ampules

These glass ampoules are commonly used for small volume lyophilization samples. Pre-scored for easy opening.

Standard Ampoules

Commonly used for packaging of certified standards.

Applications of Ampoule

Pharmacy & Parapharmacy

Food supplement

Nutricosmetics

Phytotherapy & Oligotherapy

Medical & Dental

Veterinarian

Process of Ampoule

1. Sizing

Two dimensional dimensions are essential for a glass ampoule:
the tip diameter determines the correct filling process.
the total length determines the correct path of the glass ampoules on the finishing line. The vertical machine sometimes produces short ampoules which, during finishing operations, can get in the way of the line and cause all the following ampoules to fall off, or even damage the printing screen.

2. Printing

The printing of the glass ampoules includes the inscriptions required by the customer laboratory. The printing is done by screen printing, using a glass enamel that must be baked.
The screens on which the glass enamel is applied are made from template (transparent film printed in black). The glass ampoule is lifted from the chain by a crowbar with rollers. It is positioned under the screen, which is animated by an alternating translation movement synchronized with the chain. It is therefore the screen that drives the ampoule in rotation, while the scraper passes the enamel through the mesh.
One glass ampoule is printed in the movement of the screen from left to right, and the next ampoule in the return movement.

3. Annealing

The enamel of the printed glass ampoules needs to be annealed, as does the enamel used in the Self-breaking process (see below).
The annealing takes place in an oven, which is a tunnel kiln in which the glass ampoules travel. The temperature is around 600°C and the annealing time depends on the speed at which the ampoules move and the length of the oven.
If the annealing is insufficient, internal tensions may remain, detectable with a polariscope and/or the print will not hold. On the other hand, if the annealing is too strong, there is a risk of deforming the glass ampoules (often referred to as "bananas").

4. Self-Breaking

In order to avoid the use of this file, various self-breakable techniques have been developed. These breakables must be sufficiently fragile for the glass ampoule to open without difficulty, and at the same time sufficiently strong for the ampoule to withstand transport, filling, sealing, packaging (racking and boxing), etc.
Controlling the breaking force (the effort required to open the glass ampoule) is the main difficulty in making a good self-breakable. In addition, it must not generate any risk of leakage or of air entering the filled and closed ampoule and must not release any glass particles when opened.

5. Packaging of Glass Ampoules

At the end of the production line, after preliminaries and annealing, the glass ampoules are placed in polypropylene boxes, using automatic "automatic packers". The number of glass ampoules per box varies from 110 to 504, depending on the capacity of the ampoules.
The glass ampoules are delivered to the customer laboratory in the plastic box with the top open, and the customer laboratory fills the ampoules and seals them.

Certificate

Our company has worked out a set of perfect quality control system, among those from our competitors which is the first one that is ISO9002 and ISO9001:2008 certified successfully.
Our products are kept on the DMF record by FDA:
DMF Number Assigned:21564.
Low-borosilicate glass tubular injection vials: DMF Number Assigned: 21564
DMF Number Assigned:21565.
Neutral-borosilicate glass tubular injection vials: DMF Number Assigned: 21565

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Our Factory

Our company is the first to build a 3d warehouse in the same industry in China, mechanical automation closed warehouse, dust free storage, reducing the risk of mis-sending and mixing.

Frequently Asked Questions

Q: What is the use of ampoule?

A: In 2021, 42% of all commercial injectable solutions worldwide were stored in glass ampoules. Owing to their numerous properties, they continue to be one of the preferred pharmaceutical containers. Made of 100% glass, ampoules are tamper safe and offer high chemical resistance and excellent extractable and leachable profiles. Since ampoules are hermetically sealed by melting, they also provide intrinsic container closure integrity. Among other uses, ampoules are used for the safe storage of pain medication, sedatives, drugs for the treatment of heart and/or blood problems, vitamins, minerals, emergency drugs, nausea treatment, solutions to treat overdose, etc.

Q: How Ampoules are Made?

A: In the first stage of ampoule production, the carousels are filled with glass tubes. Most of these glass tubes are made at the Gerresheimer plants in Pisa and Vineland. In the shaping process, the ampoule is shaped from the base to the tip. Then it is separated from the glass tube. As soon as one ampoule has been separated, the base of the next one is shaped and the code rings in different colours and colour combinations can then be applied.

Q: What are the parts of the ampule?

A: Ampoules often have colored rings of paint or enamel around their necks that are meant to identify the substance inside the ampoule. The rings are machine-readable and allow for accurate handling of the substance for the purposes of storage, labeling, and secondary packaging.

Q: What do ampoules generally contain?

A: Ampoules are typically made of glass. Current ampoules are most ordinarily used to contain drugs and synthetic compounds that should be shielded from air and impurities.

Q: What is the definition of ampule?

A: Most dictionaries define an ampule (amp, ampoule) as “a hermetically sealed vial made of glass or plastic that contains a sterile medicinal solution or a powder that is usually made into a solution for subcutaneous, intramuscular, or intravenous injection.”

Q: What is the dot on the glass ampule?

A: (1)If there is a dot on the ampoule this shows where the weak point in the neck is and where the ampoule should break. Ensure the dot is facing away from you. Hold the ampoule in one hand, place the ampoule opener on to the top of the ampoule using the other hand. What is the dot on the glass ampule?
(2)If there is a dot on the ampoule this shows where the weak point in the neck is and where the ampoule should break. Ensure the dot is facing away from you. Hold the ampoule in one hand, place the ampoule opener on to the top of the ampoule using the other hand.

Q: What is the difference between a vial and an ampoule?

A: Whilst they may seem identical to the untrained eye, ampoules and vials are different storage containers with different uses. Ampoules are smaller and used to hold single-dose medicines, whereas vials tend to be larger, and the product inside can be stored and reused.

Q: What are the different types of glass ampoules?

A: These include straight-stem, funnel-type and closed ampoules of ISO types B, C and D with various break systems such as OPC (One Point Cut), CBR (Color Break Ring) and Score Ring. In addition to the ISO norms customized shapes are available on request.

Q: What are the risks of glass ampoules?

A: Glass ampoules containing drugs used in patient therapy are the most common cause of occupational injury among healthcare workers, particularly nurses. Glass particles have also been shown to contaminate the ampoules during ampoule breaking. These can then be transferred to the patient by injection.

Q: How are glass ampoules manufactured?

A: The ampoule for storing and keeping an injection is manufactured by; heating and drawing longitudinally a glass tube; forming head and neck portions of the ampoule; dividing the glass tube into two to heat the interface between elongated and unelongated parts, the ampoule being formed with the lower part of the divided glass; drawing a cutting line on the circumference of end part of the amploule; heating the cutting line to be weak; cutting along cutting line to apply a shock or a vibration; coating the neck portion of the ampoule with a pigment to be easy to cut afterwards; printing volume and name of the injection and producer on surface of the ampoule; and heating the amploule to infiltrate the coated pigment into the glass and to strengthen the elongated part.

Q: Do you inject air into glass ampule?

A: Inject air into the ampule before withdrawing the medication. Hold the ampule horizontally while inserting the filter needle. Expel air bubbles from the syringe while the filter needle is still inside the ampule.

Q: How many doses are in an ampule?

A: Ampules are glass containers in 1 ml to 10 ml sizes that hold a single dose of medication in liquid form.

Q: Why are ampoules used in pharmacy?

A: The way that an ampoule is sealed shut means that the chemical compound inside is protected from exterior elements like oxygen. Because they cannot be reused, ampoules are usually used to store and transport single doses of medicines or samples.

We're well-known as one of the leading ampoule manufacturers and suppliers in China. If you're going to buy high quality ampoule, welcome to get more information from our factory. Also, customized service is available.

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